How to improve the transdermal absorption rate of the raw material of Pro-Xylane

I. Formulation Technology Innovation

In the cosmetics and skincare industry, enhancing the transdermal absorption rate of boswellic acid is crucial. Supramolecular solvent systems, such as SHINE+ Dual-Engine Boswellic Acid from Shenzhen Shanhai and the fourth-generation supramolecular dual-peak boswellic acid from Sichuan Peimei, utilize organic acids and amino acids to form supramolecular structures with boswellic acid, overcoming the barrier of the stratum corneum and improving transdermal efficiency. L’Oréal’s Dual Permeation Micropump technology enhances boswellic acid’s penetration through the stratum corneum and targeting of the dermis through a meticulously designed delivery system, significantly increasing its skin absorption rate.

II. Physical and Chemical Penetration Enhancement Methods

Nanocarrier encapsulation technology, such as hyaluronic acid-liposome complexes, improves the stability and permeability of boswellic acid through nanoscale encapsulation. Penetration enhancer assistance is divided into small-molecule penetration enhancers and natural penetration ingredients. Small-molecule penetration enhancers like propylene glycol and Azone enhance penetration by disrupting the lipid arrangement of the stratum corneum, while natural penetration ingredients like menthol derivatives and essential oils promote absorption by dilating follicular openings.

III. Process and Dosage Form Optimization

Crystallization morphology control employs an ethanol resolubilization-seed-induced crystallization process to convert boswellic acid from an oily crude product into a high-purity crystalline form, improving transdermal absorption efficiency. Dosage form adaptability design, such as water-based gel formulations suitable for dry skin and microemulsion systems that enhance boswellic acid solubility and reduce skin barrier resistance.

IV. Biotechnological Engineering Breakthroughs

Molecular structure modification, such as hydroxyl or glycosylation modifications to boswellic acid, reduces molecular polarity and increases transdermal rate. Enzymatic activation technology, like the addition of keratinase Keratase, gently exfoliates dead cells from the stratum corneum, promoting the penetration of boswellic acid into the dermis.

V. Application Scenarios and Synergistic Effects

Combining with phototherapy, such as using boswellic acid-containing products after radiofrequency or microneedle treatments, utilizes skin microchannels to improve absorption rates. Multi-active ingredient combinations, such as boswellic acid with nicotinamide and acetyl hexapeptide-8, form a synergistic anti-aging network, enhancing skincare effectiveness.

Summary

Enhancing the transdermal absorption of boswellic acid requires a combination of multiple technological approaches. Supramolecular delivery systems and dual permeation technologies overcome stratum corneum barriers, while nanocarriers and penetration enhancers enhance targeting and penetration efficiency. Dosage form optimization and molecular modifications improve physicochemical properties. In the future, the integration of AI to simulate permeation pathways and develop personalized dosage forms can achieve precise transdermal regulation and efficient personalized skincare experiences.

提升玻色因透皮吸收需综合多种技术手段。超分子递送体系和双渗透技术突破角质层屏障，纳米载体与促渗剂增强靶向性和渗透效率，剂型优化与分子修饰改善理化特性。未来可结合AI模拟渗透路径和个性化剂型开发，实现精准透皮调控和高效个性化护肤体验。