Proxylane Bulk Powder must undergo scientific formulation and process optimization to fully unlock its anti-aging potential. It is recommended for high-performance categories such as serums and eye creams, with emphasis on pH control and packaging stability. For DIY users, strict dosage control (≤2%) and prior skin tolerance testing are strongly advised.
I. Basic Characteristics of Proxylane Bulk Powder
(A) Physical Properties
- Appearance & Morphology:
Pro-xylane pure powder is White or off-white powder with no visible impurities. - Solubility:
- Highly water-soluble (≈15 g/100 mL at 25°C), solubility increases with temperature.
- Sparingly soluble in organic solvents (e.g., ethanol, propylene glycol); insoluble in lipophilic solvents (e.g., mineral oil, silicone oil).
- Particle Characteristics:
- Micronized powder (D50 ≤ 20 μm), requiring sieving for flowability.
- Bulk density: 0.3–0.5 g/cm³; auxiliary agents may be needed to improve dispersion.
- Thermal Stability:
- Withstands short-term heating up to 80–100°C in dry conditions; degradation risk above 120°C.
- Melting point: ≈130–140°C (decomposition temperature; avoid prolonged exposure to molten state).
- Hygroscopicity:
- Sensitive to humidity (>60% RH); store in sealed containers (<40% RH).
(B) Chemical Properties
- Molecular Structure:
- Formula: C₁₅H₃₀O₅ | Molecular Weight: 286.4 g/mol.
- Functional Groups: Three hydroxyl (-OH) groups and one ether (-O-) bond, conferring hydrophilicity and chemical stability.
- pH Sensitivity:
- Optimal stability at pH 5.0–7.0 (recommended range: 6.0–6.5).
- Risk of hydrolysis or oxidation in extreme pH environments (<3 or >9).
- Oxidation & Degradation:
- Requires antioxidants (e.g., EDTA disodium, BHT) to prevent oxidative deterioration.
- Degradation pathways: Ether bond cleavage under prolonged light/heat exposure.
(C) Compatibility with Active Ingredients
- Synergistic Components:
- Hyaluronic acid, peptides: Pro-Xylane ingredients can Enhance moisturization and anti-aging effects (synergy validation required).
- Conflicting Components:
- Avoid high-concentration AHAs/BHAs, strong oxidants (e.g., VC derivatives), or chelators (e.g., EDTA).
- Oxidative Degradation:
- Add antioxidants to mitigate oxidation risks.
II. Key Considerations in Cosmetic Formulation of Pro-Xylane
(A) Preprocessing & Storage of Proxylane Bulk Powder
- Moisture Control:
- Store in low-humidity (<40%), temperature-controlled (15–25°C) environments.
- Use aluminum foil bags or nitrogen-flushed containers to prevent oxidation.
- Dispersion Optimization:
- Pre-disperse powder in partial solvent via high-shear equipment (e.g., homogenizer).
- Sieve particles (e.g., 20 μm mesh) to ensure uniformity (D90 ≤ 30 μm).
(B) Formula Compatibility Design
- Solvent System:
- Aqueous Formulas: Use deionized/softened water to avoid mineral interference.
- Organic Solvents: Validate HSP compatibility with polyols (e.g., propylene glycol).
- pH Stability:
- Maintain pH 5.0–7.0 (buffer with 0.1–0.3% lactic acid/citric acid).
- Ingredient Synergy/Antagonism:
- Enhance efficacy with hyaluronic acid/polypeptides; avoid AHAs, BHA, or EDTA.
(C) Bosein Production Process Optimization
- Dissolution Parameters:
- Temperature ≤40°C (avoid >120°C); stir at 200–400 rpm to minimize shear degradation.
- Dissolve Proxylane in warm water first, then gradually add other aqueous components.
- Emulsification & Thickening:
- Use nonionic emulsifiers (e.g., PEG-40 hydrogenated castor oil).
- Combine carbomer (0.1–0.3%) and hydroxyethyl cellulose (0.05–0.1%) for viscosity (1000–3000 mPa·s).
- Homogenization & Filtration:
- Secondary homogenization pressure: 15–20 MPa (target D90 ≤5 μm).
- Sterile filtration (0.22 μm) to remove particulates/microbes.
(D) Stability Control & Packaging of Bosein formulator
- Light/Heat Protection:
- Amber PET bottles or aluminum tubes for UV shielding (<400 nm).
- Cold-chain transport (2–8°C) for oxidative-sensitive formulations.
- Accelerated Stability Testing:
- Test conditions: 40°C/75% RH/1.2×10⁶ lux for 3 months.
- Key metrics: pH change ≤0.5, viscosity fluctuation ≤10%, no precipitation/discoloration.
(E) Regulatory & Safety Validation related with Bosein
- Compliance:
- Concentration limit: ≤5% (new ingredients require regulatory filing).
- Provide cytotoxicity (MTT), sensitization (HET-CAM), and human patch test reports.
- Labeling:
- INCI name: “Proxylane” or “Hydroxypropyl Tetrahydro Pyrantriol”.
- Efficacy claims: Support with 28-day human trials (e.g., ≥10% skin elasticity improvement).
(F) Equipment & Process Validation
- Specialized Equipment:
- Temperature-controlled dissolution tanks (±1°C precision) with inline viscosity monitoring.
- Nitrogen-purged filling lines to reduce oxidation risks.
- Process Validation:
- Define control ranges for temperature, pH, and shear rate via DOE optimization.
- Residue testing (HPLC: Proxylane ≤10 ppm) for equipment cleaning validation.
III. Summary
Proxylane Bulk Powder requires systematic optimization across solubility, stability, and compatibility. By addressing technical parameters, packaging safeguards, and stringent quality control—aligned with pharmaceutical-grade standards (e.g., GMP)—formulators can ensure its efficacious and safe application in skincare products.
Proxylane pure
Supplying pure powder of Bosein ,proxylane
